Document 0077
 DOCN  M9470077
 TI    Cerebrovascular and neurological disorders associated with
       antiphospholipid antibodies in CSF and serum.
 DT    9409
 AU    Gallo P; Sivieri S; Ferrarini AM; Giometto B; Ruffatti A; Ritter E;
       Chizzolini C; Tavolato B; Institute of Neurology, University of Padua,
       School of Medicine,; Italy.
 SO    J Neurol Sci. 1994 Mar;122(1):97-101. Unique Identifier : AIDSLINE
       MED/94253843
 AB    Paired serum and cerebrospinal fluid (CSF) samples from 70 patients with
       inflammatory and non-inflammatory neurological diseases, as well as 10
       sera from patients with primary antiphospholipid syndrome (PAS), six of
       which presented with cerebrovascular ischemic syndromes, were studied
       for the presence of anticardiolipin antibodies (ACA) of the G and M
       classes. PAS sera and some selected paired CSF and serum specimens, were
       also analyzed for the presence of anti-phosphatidylserine (PS) and
       anti-phosphatidylethanolamine (PE) antibodies. High levels of IgG and
       IgM ACA were synthesized intrathecally only in patients with
       neurosyphilis. Patients with other infectious or inflammatory
       neurological diseases very rarely showed detectable levels of ACA in
       serum and/or CSF. ACA were found not only in patients with untreated PAS
       but also in the serum of 3/7 patients with migraine, thus confirming a
       relationship between ACA and vascular disorders. The search for PS and
       PE antibodies disclosed that in PAS patients the serum titers of these
       antibodies mirrored ACA IgG and IgM titers, while they were never found
       in the CSF.
 DE    Adolescence  Adult  Antibodies,
       Anticardiolipin/ANALYSIS/BLOOD/CEREBROSPINAL FLUID  Antibodies,
       Antiphospholipid/*ANALYSIS/BLOOD/CEREBROSPINAL FLUID  Cerebral
       Ischemia/BLOOD/CEREBROSPINAL FLUID/IMMUNOLOGY  Cerebrovascular
       Disorders/BLOOD/CEREBROSPINAL FLUID/*IMMUNOLOGY  Enzyme-Linked
       Immunosorbent Assay  Female  Human  HIV Infections/BLOOD/CEREBROSPINAL
       FLUID/IMMUNOLOGY  HIV-1  IgG/BIOSYNTHESIS/CEREBROSPINAL FLUID
       IgM/BIOSYNTHESIS/CEREBROSPINAL FLUID  Lipid Metabolism, Inborn
       Errors/BLOOD/CEREBROSPINAL FLUID/  METABOLISM  Male  Middle Age
       Migraine/BLOOD/CEREBROSPINAL FLUID/IMMUNOLOGY  Nervous System
       Diseases/BLOOD/CEREBROSPINAL FLUID/*IMMUNOLOGY
       Neurosyphilis/BLOOD/CEREBROSPINAL FLUID/IMMUNOLOGY
       Phosphatidylethanolamines/IMMUNOLOGY/METABOLISM
       Phosphatidylserines/IMMUNOLOGY/METABOLISM  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).