Document 0080
 DOCN  M9470080
 TI    Role of Fc gamma receptors in cancer and infectious disease.
 DT    9409
 AU    Wallace PK; Howell AL; Fanger MW; Department of Microbiology, Dartmouth
       Medical School, Lebanon,; New Hampshire 03756.
 SO    J Leukoc Biol. 1994 Jun;55(6):816-26. Unique Identifier : AIDSLINE
       MED/94253701
 AB    Receptors for the Fc domain of immunoglobulin G (Fc gamma R) provide an
       interface between specific humoral immunity and the cellular branch of
       the immune system through their interaction with antibody. Cross-linking
       Fc gamma R on myeloid cells triggers such diverse functions as clearance
       of immune complexes, phagocytosis of opsonized pathogens, secretion of
       reactive oxygen intermediates, and antibody-dependent cellular
       cytotoxicity. The Fc gamma R play a major role in the removal of
       antibody-coated infectious agents and are the exclusive trigger
       molecules for tumor cell killing by human myeloid cells. Studies of Fc
       gamma R function have been aided by the use of Fc gamma R specific
       monoclonal antibodies, self-directed target cells, and bispecific
       antibodies that link target cells or pathogens to specific host cell
       molecules, including Fc gamma R. These reagents have contributed
       significantly to our understanding of the role of the different classes
       of Fc gamma R in mediating protection from various infectious agents and
       in mediating tumor cell killing. Taken together, these approaches have
       provided insight into the utility of manipulating Fc gamma R function in
       the therapy of cancer and infectious disease.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY  Animal  Communicable
       Diseases/*IMMUNOLOGY  Cytotoxicity, Immunologic  Human  HIV-1
       Neoplasms/*IMMUNOLOGY  Polymorphism (Genetics)  Receptors,
       IgG/GENETICS/*PHYSIOLOGY  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       Non-P.H.S.  Support, U.S. Gov't, P.H.S.  Toxoplasma/IMMUNOLOGY  JOURNAL
       ARTICLE  REVIEW  REVIEW, ACADEMIC

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).