Document 0084
 DOCN  M9470084
 TI    False-positive rapid plasma reagin tests in human immunodeficiency virus
       infection and relationship to anti-cardiolipin antibody and serum
       immunoglobulin levels.
 DT    9409
 AU    Rusnak JM; Butzin C; McGlasson D; Blatt SP; Department of Infectious
       Diseases, Wilford Hall Medical Center,; Lackland Air Force Base, Texas
       78236-5300.
 SO    J Infect Dis. 1994 Jun;169(6):1356-9. Unique Identifier : AIDSLINE
       MED/94253600
 AB    The incidence of biologic false-positive rapid plasma reagin (RPR) tests
       may be increased in human immunodeficiency virus (HIV) infection;
       however, injecting drug use has not been excluded as the cause. Review
       of 3371 periodic syphilis serology results from 1077 HIV-seropositive
       patients in the United States Air Force HIV Natural History Study
       between January 1986 and June 1992 revealed a cumulative biologic
       false-positive RPR rate of 1%. Most (6/9) were transient low-titer
       results associated with a recent acute infectious process.
       False-positive RPR tests did not appear to correlate with
       anticardiolipin antibody levels or serum IgG or IgA levels, which are
       increased in HIV infection. Although not statistically significant,
       there was a trend toward higher IgM levels in patients with biologic
       false-positive tests. Thus, the incidence of false-positive RPR in an
       HIV-infected population with a low risk of injecting drug use is similar
       to that in the general population, and the mechanism may correlate with
       elevated serum IgM levels.
 DE    Analysis of Variance  Antibodies, Anticardiolipin/*BLOOD  Antibodies,
       Viral/IMMUNOLOGY  False Positive Reactions  Female  Human  HIV
       Infections/BLOOD/*DIAGNOSIS/IMMUNOLOGY  IgM/BLOOD  Male  Syphilis
       Serodiagnosis  JOURNAL ARTICLE

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