Document 0087
 DOCN  M9470087
 TI    Human herpesvirus 6 DNA in blood cells of human immunodeficiency
       virus-infected men: correlation of high levels with high CD4 cell
       counts.
 DT    9409
 AU    Fairfax MR; Schacker T; Cone RW; Collier AC; Corey L; Department of
       Laboratory Medicine, University of Washington; School of Medicine,
       Seattle 98144.
 SO    J Infect Dis. 1994 Jun;169(6):1342-5. Unique Identifier : AIDSLINE
       MED/94253597
 AB    The relationship between human herpesvirus 6 (HHV-6) and the progression
       of human immunodeficiency virus type 1 (HIV-1) infection to AIDS was
       evaluated using the polymerase chain reaction to quantitate HHV-6 genome
       equivalents in peripheral blood mononuclear cells (PBMC) and saliva of
       32 HIV-1-seropositive men. Unlike other herpesviruses, HHV-6 was found
       with higher frequency and in higher copy numbers of HIV-infected men
       with high rather than low CD4 cell counts. Among subjects with > 400 CD4
       cells/mL, 100% had detectable HHV-6 genomes in PBMC compared with 57.9%
       of subjects with < 400 CD4 cells/mL (P < .05). There was no significant
       correlation between HHV-6 antibody titer or number of amplifiable copies
       of HHV-6 DNA in saliva and stage of HIV disease or CD4 cell number.
 DE    Adult  AIDS-Related Opportunistic Infections/IMMUNOLOGY/*MICROBIOLOGY
       DNA, Viral/*BLOOD  Herpesviridae Infections/*COMPLICATIONS/MICROBIOLOGY
       Herpesvirus 6, Human/GENETICS/*ISOLATION & PURIF  Human  Leukocyte Count
       Male  Middle Age  Support, U.S. Gov't, P.H.S.  T4
       Lymphocytes/CYTOLOGY/*IMMUNOLOGY  JOURNAL ARTICLE

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