Document 0092
 DOCN  M9470092
 TI    Characteristics of long-term asymptomatic infection with human
       immunodeficiency virus type 1 in men with normal and low CD4+ cell
       counts.
 DT    9409
 AU    Keet IP; Krol A; Klein MR; Veugelers P; de Wit J; Roos M; Koot M;
       Goudsmit J; Miedema F; Coutinho RA; Municipal Health Service, Department
       of Public Health and; Environment, Amsterdam, Netherlands.
 SO    J Infect Dis. 1994 Jun;169(6):1236-43. Unique Identifier : AIDSLINE
       MED/94253580
 AB    From a cohort study of homosexual men in Amsterdam, 61 human
       immunodeficiency virus (HIV)-infected men who had remained asymptomatic
       for at least 7 years were identified. In a nested case control study,
       these men were compared with 142 men who progressed symptomatic HIV
       infection (CDC class IV) within 7 years, regarding laboratory markers,
       sexual behavior, psychologic coping, and drug use. Of the 61 long-term
       asymptomatic men, 13 had a CD4+ cell count > or = 500/mm3 after 7 years;
       in 2 of these 13, the CD4+ cell count had not declined during follow-up.
       Independent of CD4+ cell count, long-term asymptomatic HIV-1 infection
       was characterized by stable T cell reactivity after stimulation with
       monoclonal CD3 antibodies, seropositivity for antibodies to HIV core
       proteins, and the absence of hepatitis B markers. No association with
       markers of high-risk sex or the recreational use of drugs was found.
       Long-term asymptomatic men had a slightly lower score regarding the
       coping behavior active problem-solving; no other associations with
       coping behaviors were found.
 DE    Adult  Case-Control Studies  Cohort Studies  Follow-Up Studies
       Homosexuality  Human  HIV
       Infections/EPIDEMIOLOGY/*IMMUNOLOGY/PHYSIOPATHOLOGY  HIV-1/*IMMUNOLOGY
       Immunity, Natural  Leukocyte Count  Male  Reference Values  Sex Behavior
       Substance Abuse  T4 Lymphocytes/CYTOLOGY/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).