Document 0140
 DOCN  M9470140
 TI    Oxygen radical release by neutrophils of HIV-infected patients.
 DT    9409
 AU    Jarstrand C; Akerlund B; Department for Clinical Microbiology, Huddinge
       University; Hospital, Sweden.
 SO    Chem Biol Interact. 1994 Jun;91(2-3):141-6. Unique Identifier : AIDSLINE
       MED/94251840
 AB    Neutrophils from asymptomatic HIV-infected patients have an increased
       Nitroblue tetrazolium (NBT) reduction, that is an increased production
       of oxygen radicals. Plasma from these patients can activate normal
       neutrophils to an increased NBT-reduction and the neutrophil activating
       factor thus seems to be mainly plasma bound. Further, the patients also
       have increased levels of plasma malondialdehyde and thus an increased
       lipid peroxidation. Plasma cysteine levels are low, a sign of increased
       consumption of antioxidants. Treatment of the asymptomatic HIV-infected
       patients with N-acetylcysteine corrected the plasma cysteine levels and
       had some beneficial effects, but did not inhibit the increased radical
       production by the neutrophils.
 DE    Acetylcysteine/*THERAPEUTIC USE  Acquired Immunodeficiency
       Syndrome/BLOOD  Adult  AIDS-Related Complex/BLOOD  Cysteine/BLOOD
       Female  Free Radicals  Human  HIV Infections/*BLOOD/DRUG THERAPY  Male
       Neutrophils/*METABOLISM  Oxidation-Reduction  Randomized Controlled
       Trials  Superoxides/*BLOOD  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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