Document 0143
 DOCN  M9470143
 TI    Ultraviolet irradiation and cytokines as regulators of HIV latency and
       expression.
 DT    9409
 AU    Vicenzi E; Poli G; AIDS Immunopathogenesis Unit, San Raffaele Hospital,
       Centro San; Luigi, Milan, Italy.
 SO    Chem Biol Interact. 1994 Jun;91(2-3):101-9. Unique Identifier : AIDSLINE
       MED/94251836
 AB    The ability of the human immunodeficiency virus (HIV) to persist and
       replicate in human CD4+ T lymphocytes and mononuclear phagocytes is
       under the control of both virally encoded proteins and a variety of
       host-related factors. Ultraviolet (UV) light has been shown to induce
       transcription and expression of HIV. Both DNA damage and repair and DNA
       damage/repair-independent pathways caused by UV irradiation lead to
       expression of proviral HIV genomes via activation of the cellular
       transcription factor NF-kappa B. Transgenic mice that contain either
       long terminal repeat (LTR)-reporter genes or HIV genomes, either full
       length or deleted in the gag-pol region, express RNA and proteins at the
       epidermal level, particularly after UV irradiation. Furthermore,
       UV-triggered release of soluble factors capable of inducing expression
       of HIV in non-irradiated cells has been observed. Among other host
       factors, the functional network of pro-inflammatory and immunoregulatory
       cytokines has been demonstrated to act as a potent regulator of HIV
       replication, at least in different in vitro systems of infection.
 DE    Animal  Cytokines/PHARMACOLOGY/*PHYSIOLOGY  Gene Expression Regulation,
       Viral/DRUG EFFECTS/RADIATION EFFECTS  Human  HIV/DRUG
       EFFECTS/GENETICS/*PHYSIOLOGY/RADIATION EFFECTS  Mice  Mice, Transgenic
       NF-kappa B/METABOLISM  *Ultraviolet Rays  Up-Regulation (Physiology)
       Virus Activation/DRUG EFFECTS/RADIATION EFFECTS  *Virus Latency/DRUG
       EFFECTS/RADIATION EFFECTS  Virus Replication/DRUG EFFECTS/RADIATION
       EFFECTS  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).