Document 0144
 DOCN  M9470144
 TI    Selective effects of human immunodeficiency virus (HIV) gp120 on
       invertebrate neurons.
 DT    9409
 AU    Stefano GB; Sawada M; Smith EM; Hughes TK; Old Westbury Neuroscience
       Research Institute, State University of; New York at Old Westbury
       11568-0210.
 SO    Cell Mol Neurobiol. 1993 Dec;13(6):569-77. Unique Identifier : AIDSLINE
       MED/94251782
 AB    1. HIV gp120 selectively reduces the glutamate-induced inward current
       and the acetylcholine-induced outward current in specific and identified
       Aplysia neurons without affecting dopamine (DA)- and serotonin
       (5-HT)-induced responses. 2. gp120 specifically decreases DA levels
       without significantly altering norepinephrine and 5-HT levels in Mytilus
       pedal ganglia. 3. The gp120-associated decrease in DA levels in Mytilus
       is dose dependent and exhibits a threshold level. 4. The alteration of
       in vitro DA levels is specific for gp120 since anti-gp120 blocks the
       effect. 5. gp120 and its effects appear to be stable due to the duration
       of treatment and the failure of secondary effects to materialize
       following antibody treatment.
 DE    Acetylcholine/PHARMACOLOGY  Animal  Antibodies/PHARMACOLOGY  Aplysia
       Dopamine/METABOLISM  Ganglia, Invertebrate/*PHYSIOLOGY
       Glutamates/PHARMACOLOGY  HIV  HIV Envelope Protein
       gp120/IMMUNOLOGY/*PHARMACOLOGY  In Vitro  Membrane Potentials/DRUG
       EFFECTS/PHYSIOLOGY  Mussels  Neurons/DRUG EFFECTS/METABOLISM/*PHYSIOLOGY
       Norepinephrine/METABOLISM  Potassium Channels/DRUG EFFECTS/*PHYSIOLOGY
       Pressure  Recombinant Proteins/*PHARMACOLOGY  Serotonin/METABOLISM
       Support, Non-U.S. Gov't  Support, U.S. Gov't, Non-P.H.S.  Support, U.S.
       Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).