Document 0158
 DOCN  M9470158
 TI    Ten years after acquiring an HIV-1 infection: a study in a cohort of
       eleven neonates infected by aliquots from a single plasma donation.
 DT    9409
 AU    van den Berg H; Gerritsen EJ; van Tol MJ; Dooren LJ; Vossen JM;
       Department of Paediatrics, Leiden University Hospital, The; Netherlands.
 SO    Acta Paediatr. 1994 Feb;83(2):173-8. Unique Identifier : AIDSLINE
       MED/94251071
 AB    We present data from a 10-year follow-up study of 11 children who had
       been infected in the neonatal period by small aliquots of plasma from a
       single donation. Three of the children died within the first 2.5 years
       of life, 5 other children died between 6.2 and 11 years after infection
       and 3 are alive at present. The latter children are classified as P1B
       (asymptomatic), P2A (non-specific findings) and P2B (neurological
       changes). All infected children showed progressive decline of cellular
       immunity. Immunoglobulin levels in serum were increased in the majority
       of children for prolonged periods and homogeneous immunoglobulin
       components were present. The severity of the disease was related neither
       to the clinical condition of the infants in the neonatal period nor to
       the volume of transfused plasma, the interval between freezing and
       thawing of the plasma, gestational age at birth and age at transfusion.
       Coinciding infections with other viruses had no impact on disease
       progression during the follow-up period of 10 years.
 DE    *Blood Donors  Blood Transfusion/*ADVERSE EFFECTS  Child  Follow-Up
       Studies  Human  HIV Infections/IMMUNOLOGY/*TRANSMISSION  *HIV-1
       Immunity, Cellular  Immunoglobulins/BLOOD  Infant, Newborn  Prognosis
       JOURNAL ARTICLE

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