Document 0159
 DOCN  M9470159
 TI    Otic administration of amphotericin B 0.25% in sterile water.
 DT    9409
 AU    Kintzel PE; Trausch DE; Copfer AL; Inpatient Pharmacy, University
       Medical Center, University of; Arizona Health Sciences Center, Tucson
       85724.
 SO    Ann Pharmacother. 1994 Mar;28(3):333-5. Unique Identifier : AIDSLINE
       MED/94250989
 AB    OBJECTIVE: To report otic administration of parenteral amphotericin B
       0.25% in sterile water. CASE SUMMARY: A 44-year-old HIV+ man was
       diagnosed with otitis externa. The patient's past medical history was
       remarkable for positive Coccidioides immitis serology for more than five
       months, essential hypertension, and Barrett's esophagitis. Culture
       results from an ear swab revealed 4+ Aspergillus fumigatus and 3+
       Staphylococcus, coagulase negative. Antiinfective therapy for the otitis
       externa included oral and topical antibacterial and antifungal
       medications. Amphotericin B 0.25% in sterile water was prepared by the
       pharmacy for topical otic administration. The otic amphotericin B was
       dispensed with instructions to refrigerate and assigned a one-week
       expiration date. The prescription called for instillation of 1-2 drops
       in each ear three times a day. The patient's signs and symptoms of
       otitis externa resolved during several weeks of antiinfective therapy.
       Topical administration of amphotericin B 0.25% in sterile water was not
       associated with any local adverse effects in this patient. DISCUSSION:
       The rationale for use of the parenteral amphotericin B formulation to
       prepare an otic dosage form, and the rationale for the specific
       concentration and expiration date chosen are discussed. CONCLUSIONS:
       This patient tolerated topical otic administration of amphotericin B
       0.25% in sterile water when administered three times daily.
 DE    Administration, Topical  Adult  Amphotericin B/*ADMINISTRATION &
       DOSAGE/THERAPEUTIC USE  Aspergillosis/*DRUG THERAPY  *Aspergillus
       fumigatus  Case Report  Drug Administration Routes  Drug Administration
       Schedule  Ear Canal  Human  HIV Seropositivity  Male  Otitis
       Externa/*DRUG THERAPY  Water  JOURNAL ARTICLE

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       protected by Copyright Law (Title 17, U.S.Code).