Document 0161
 DOCN  M9470161
 TI    Localization of perforin in viral vesicles and erythema multiforme [see
       comments]
 DT    9409
 AU    Sayama K; Watanabe Y; Tohyama M; Miki Y; Department of Dermatology,
       Ehime University School of Medicine,; Japan.
 SO    Dermatology. 1994;188(4):305-9. Unique Identifier : AIDSLINE
       MED/94250972
 CM    Comment in: Dermatology 1994;188(4):249-50
 AB    BACKGROUND: Perforin (Pf), a pore-forming protein, is a cytolytic
       protein of killer cells. Its deposition in lesioned skin has not been
       studied. OBJECTIVE: The purpose of this study is to show Pf deposition
       in the lesioned skin and Pf expression in the dermal infiltrates of
       various inflammatory skin diseases. METHODS: Frozen specimens obtained
       from 29 patients with 5 different diseases were immunohistochemically
       stained. RESULTS: Granular deposition of Pf was found in the lesioned
       skin in 2 out of 5 cases of viral vesicles and in 3 out of 7 cases of
       erythema multiforme. In the cases with Pf deposition, the percentages of
       Pf+ cells in the dermis were higher than in those without deposition.
       CONCLUSION: Pf released from natural killer cells or cytotoxic T
       lymphocytes may play a role in tissue damage.
 DE    Adolescence  Adult  Aged  Child  CD4-CD8 Ratio  Dermatitis,
       Contact/METABOLISM/PATHOLOGY  Erythema Multiforme/METABOLISM/*PATHOLOGY
       Female  Herpes Zoster/METABOLISM/*PATHOLOGY  Human  Killer Cells,
       Natural/CHEMISTRY/PATHOLOGY  Lichenoid Eruptions/METABOLISM/PATHOLOGY
       Male  Membrane Glycoproteins/*ANALYSIS  Middle Age  Pemphigoid,
       Bullous/METABOLISM/PATHOLOGY  Skin/CHEMISTRY/PATHOLOGY  Skin Diseases,
       Viral/METABOLISM/*PATHOLOGY  Stains and Staining  T-Lymphocytes,
       Cytotoxic/CHEMISTRY/*PATHOLOGY  JOURNAL ARTICLE

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