Document 0843
 DOCN  M9480843
 TI    A similar microbiologic profile in HIV-seropositive (HIV+) and
       seronegative (HIV-) women with pelvic inflammatory disease (PID).
       Multicenter HIV and PID Study Group.
 DT    9410
 AU    Moorman A; Rice R; Irwin K; O'Sullivan M; Sperling R; Brodman M; Droese
       A; CDC, Atlanta, GA.
 SO    Abstr Gen Meet Am Soc Microbiol. 1994;94:553 (abstract no. C-356).
       Unique Identifier : AIDSLINE ASM94/94313102
 AB    To compare the microbiologic findings in HIV+ women with PID who may be
       immunosuppressed with those in HIV- women with PID, we started a
       prospective study in 1992 at two urban hospitals to evaluate women who
       have had PID diagnosed using standard criteria. Vaginal and endocervical
       secretions and endometrial biopsy tissue were tested for bacteria,
       viruses, and fungi, including common etiologic agents of PID.
       Preliminary data indicate that endometritis, based on standard
       histopathologic criteria, is significantly more common in HIV+ than HIV-
       women (HIV+ 7/10(70%), HIV- 17/55(31%), p < .05). HIV+ women tested to
       date were more likely than HIV- women to have endocervical human
       papilloma virus (HPV), including types associated with dysplasia (HIV+
       5/13(38%), HIV- 9/61(15%), p = .06). There were no significant
       differences between HIV+ and HIV- women in bacteria or fungi recovered
       from the vagina, cervix, or endometrium: endocervical gonorrhea, HIV+
       7/20(35%), HIV- 27/89(30%); endometrial gonorrhea, HIV+ 4/17(24%), HIV-
       20/77(26%); endocervical chlamydia culture, HIV+ 2/11(18%), HIV-
       11/67(16%); endocervical chlamydia DFA, HIV+ 5/17(29%), HIV- 18/81(22%);
       endometrial chlamydia, HIV+ 1/10(10%), HIV- 5/58(9%); endometrial
       facultative bacteria, HIV+ 9/16(56%), HIV- 54/74(72%); endometrial
       anaerobic bacteria, HIV+ 0/16, HIV- 10/76(13%). Preliminary data
       indicate that the microbiologic findings in HIV+ and HIV- women with PID
       appear similar. Our data do not suggest a need for changes in standard
       antibiotic treatment, but highlight the need for PAP smear screening for
       HPV cytologic changes.
 DE    Adnexitis/EPIDEMIOLOGY/*MICROBIOLOGY  Bacteria/ISOLATION & PURIF  Cervix
       Uteri/MICROBIOLOGY  Chlamydia Infections/EPIDEMIOLOGY  Comparative Study
       Endometrium/MICROBIOLOGY  Female  Fungi/ISOLATION & PURIF
       Gonorrhea/EPIDEMIOLOGY  Hospitals, Urban  Human  *HIV Seronegativity
       HIV Seropositivity/*MICROBIOLOGY  Prospective Studies
       Vagina/MICROBIOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).