Document 0853
 DOCN  M9480853
 TI    Plasma-levels of IL-2R and IL-6 in perinatally HIV-infected children.
 DT    9410
 AU    Fendt D; Cruciani M; Fioredda F; Loy A; Concia E; Bassetti D; Institute
       of Infectious Diseases, University of Verona, Italy.
 SO    Abstr Gen Meet Am Soc Microbiol. 1994;94:484 (abstract no. T-12). Unique
       Identifier : AIDSLINE ASM94/94313092
 AB    OBJECTIVE: The relationship between plasma-levels of IL-2R and IL-6,
       known prognostic markers of HIV-infection (CD4 count, p24 antigenemia)
       and progression into symptomatic disease in children was investigated.
       METHODS: 10 children (5 male, 5 female, aged 3-7 years) with perinatal
       HIV-infection in different clinical stages were included in a
       prospective study with follow-up over a one-year period. At study entry
       2 pts. were classified in stage P1B, 3 in P2A, 2 in P2AF and 3 in AIDS.
       Four children were p24-antigenemia negative and had CD4 count > 400/mm3
       (> 20%) (Group I), while 6 pts. had positive p24 antigenemia and CD4
       count < 400/mm3 (< 20%) (Group II). Every 3 months clinical/nutritional
       status, CD4 count and p24 antigenemia were evaluated and plasma samples
       were stored for determination of IL-2R and IL-6 levels by ELISA-testing.
       RESULTS: Levels of IL-R ranged from 217-884 U/ml. There was significant
       difference between IL-2R levels found in Group I (mean value 248 U/ml,
       range 217-289 U/ml) and those found in Group II (mean value 360 U/ml,
       range 235-884 U/ml) (p < 0.001). One child of Group II had disease
       progression in AIDS during follow-up (CMV-chorioretinitis) preceded 4
       months before diagnosis by 2-fold increase of IL-2R levels.
       Plasma-levels of IL-6 ranged from 0-270 pg/ml. Positive determinations >
       10 pg/ml were found significantly more frequently in patients in stage
       P2AF and AIDS (p < 0.02) and exclusively in children with deficit of
       weight for height (wasting score < 97) (p < 0.001). No clear
       relationship between CD4-count, p24 antigenemia and plasma IL-6 levels
       was found. CONCLUSION: Monitoring plasma-levels of IL-2R and IL-6 may
       have prognostic value in perinatal HIV-infection. Further observations
       would be needed to confirm these findings.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/IMMUNOLOGY  Biological
       Markers/BLOOD  Child  Child, Preschool  Enzyme-Linked Immunosorbent
       Assay/METHODS  Female  Human  HIV
       Infections/*BLOOD/IMMUNOLOGY/TRANSMISSION  Interleukin-6/*BLOOD  Male
       Monitoring, Physiologic  Pregnancy  Pregnancy Complications, Infectious
       Receptors, Interleukin-2/*ANALYSIS  MEETING ABSTRACT

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