Document 0856
 DOCN  M9480856
 TI    Antibody profile and isotypic patterns on HIV infected patients under
       drug treatment.
 DT    9410
 AU    Rivera L; Montealegre F; Diaz AM; Univ. of P.R.
 SO    Abstr Gen Meet Am Soc Microbiol. 1994;94:484 (abstract no. T-11). Unique
       Identifier : AIDSLINE ASM94/94313089
 AB    In this study we correlated the isotype and specificity of the IgG
       antibody response from 100 Puerto Rican HIV-infected patients with the
       treatment which they were given. Western Blots have been performed to
       determine the isotype as well as protein specificity of antibodies
       contained in the patient's serum. Clinical data like sex, age, rate of
       infection, stage according to the classification of CDC, number of T-CD4
       cells, antiviral treatment and treatment against opportunistic infection
       were collected from patient's records that were treated in P.R. Concra.
       The detection of isotypes by Western Blots allowed an evaluation of the
       host response to specific viral proteins and the effect of drug therapy
       in the humoral response. The results of this work would be a useful tool
       for finding of the best treatment against the infection by HIV-1. The
       treatment which increases the reactivity of isotypes like IgG1, and IgG3
       which have an important role in defense as neutralizing antibodies and
       anti-HIV ADCC, have been determined.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/*DRUG THERAPY/  *IMMUNOLOGY
       Antibody Formation  Antiviral Agents/*THERAPEUTIC USE  Blotting, Western
       Female  Human  HIV Infections/BLOOD/*DRUG THERAPY/*IMMUNOLOGY  *HIV-1
       IgG/*BLOOD/CLASSIFICATION  Immunoglobulin Isotypes/*BLOOD  Male  T4
       Lymphocytes/IMMUNOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).