Document 0875
 DOCN  M9480875
 TI    Effect of HIV-1 infection on natural killer cells and neutrophils of
       chimpanzees.
 DT    9410
 AU    Javadian MA; Lafrado LJ; Couch RC; Marr JM; Boisford JL; Coulston
       Foundation, WSRC, Alamogordo, NM.
 SO    Abstr Gen Meet Am Soc Microbiol. 1994;94:158 (abstract no. E-85). Unique
       Identifier : AIDSLINE ASM94/94313070
 AB    Human infection with HIV-1 is characterized by a variety of profound
       defects in cellular immunity, including depression in natural killer
       (NK) cell activity and phagocytic activity of neutrophils which perform
       important inflammatory and immune functions. In the present experiment,
       natural killer cell and neutrophil phagocytic activities of HIV-1
       infected chimpanzees were assayed against the erythroleukemia cell line
       K562 and fluorescent latex beads, respectively. In addition, the in
       vitro effect of interleukin-2 (IL-2) on depressed NK cells was
       evaluated. Data obtained from this study demonstrate that NK cell
       activity in HIV-1 infected chimpanzees was less (p < 0.05) than their
       cytotoxic activity in the naive controls. The NK cell activity was
       significantly enhanced by in vitro interleukin-2 treatment of peripheral
       blood lymphocytes from both naive control and experimental chimpanzees.
       Neutrophils from HIV-1 infected animals exposed to fluorescein
       isothiocyanate (FITC) conjugated latex beads showed decreased
       phagocytosis. We conclude that HIV-1 infection in chimpanzees causes
       reduction in cytotoxic activity of NK cells and phagocytosis by
       polymorphonuclear leukocytes, as seen in humans.
 DE    Acquired Immunodeficiency Syndrome/*BLOOD/*IMMUNOLOGY  Animal  Cell Line
       Chimpansee troglodytes  Cytotoxicity, Immunologic  Human  *HIV-1  Killer
       Cells, Natural/*IMMUNOLOGY  Leukemia, Myeloid, Chronic
       Neutrophils/*PHYSIOLOGY  Phagocytosis  Tumor Cells, Cultured  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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