Document 0313
 DOCN  M9490313
 TI    Prevalence of human T cell lymphotropic virus type II in American Indian
       populations of the southwestern United States.
 DT    9411
 AU    Hjelle B; Khabbaz RF; Conway GA; North C; Green D; Kaplan JE; Department
       of Pathology, University of New Mexico School of; Medicine, Albuquerque.
 SO    Am J Trop Med Hyg. 1994 Jul;51(1):11-5. Unique Identifier : AIDSLINE
       MED/94337917
 AB    We investigated the seroprevalence of human T cell lymphotropic virus
       type II (HTLV-II) using a screening enzyme-linked immunosorbent assay
       (ELISA) and immunoblot confirmation among the predominant tribes (Pueblo
       and Athapaskan) served by two large Indian Health Service facilities in
       New Mexico. Among persons being treated for sexually transmitted
       diseases, eight (3.2%) of 250 were seropositive for HTLV II, compared
       with eight (2.1%) of 385 women attending prenatal clinics. In a survey
       of unselected patients at one of the facilities, 15 (3.4%) of 446 were
       seropositive. Of 31 seropositive subjects, 25 were infected with HTLV-II
       and six infections could not be typed. Sera from nine (29%) of the 31
       infected subjects had absorbance values less than the manufacturer's
       cutoff in the ELISA. Both Pueblo and Athapaskan groups had similar
       overall seroprevalences, but women tended to have a slightly higher
       seroprevalence than men, and seroprevalence tended to increase with age.
       These data show that HTLV-II infection is present among diverse groups
       of American Indians in the southwestern United States. Present ELISA
       screening tests, such as those used in this study, lack sensitivity to
       HTLV-II infection unless a reduced absorbance cutoff is used.
 DE    Adolescence  Adult  Aged  Blotting, Western  Child  Child, Preschool
       Enzyme-Linked Immunosorbent Assay  Female  Human  HTLV-II
       Antibodies/*BLOOD  HTLV-II Infections/COMPLICATIONS/*ETHNOLOGY
       *Indians, North American  Male  Middle Age  Pregnancy  Pregnancy
       Complications, Infectious/*ETHNOLOGY  Prevalence  Retrospective Studies
       Southwestern United States/EPIDEMIOLOGY  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE  MULTICENTER STUDY

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).