Document 0332
 DOCN  M9490332
 TI    [The principles of creating standard serum panels with a low
       concentration of HIV-1 antibodies for the quality control of commercial
       immunoenzyme test systems]
 DT    9411
 AU    Kanev AN; Gutova EA; Lomanova GA; Vorob'eva MS; Shalaev EIu;
       Zagrebel'nyi SN
 SO    Vopr Virusol. 1993 Mar-Apr;38(2):86-9. Unique Identifier : AIDSLINE
       MED/94337520
 AB    The main approaches are defined to the production of sera with the
       required concentration of antibodies to HIV by the dilution method and
       to formation on their basis of serum panels according to theoretical
       distribution of optic density (OD) values. It was shown to be
       principally possible to prepare panels of positive sera with low
       concentration of HIV-specific antibodies in a dry stable form, and their
       practical importance in the evaluation of the sensitivity of enzyme
       immunoassays was demonstrated. The evaluation of the quality of
       commercial test systems is based on the position and shape of the
       histogram of OD values distribution for panel sera for the controlled
       test systems.
 DE    Acquired Immunodeficiency Syndrome/DIAGNOSIS  Antibody Specificity  Drug
       Stability  English Abstract  Freeze Drying  Human  HIV Antibodies/*BLOOD
       HIV Infections/DIAGNOSIS  HIV-1/*IMMUNOLOGY  Immune
       Sera/IMMUNOLOGY/*ISOLATION & PURIF  Immunoenzyme
       Techniques/INSTRUMENTATION/*STANDARDS  Quality Control  Reference
       Standards  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).