Document 0365
 DOCN  M9490365
 TI    Murine AIDS protects mice against experimental cerebral malaria:
       down-regulation by interleukin 10 of a T-helper type 1 CD4+
       cell-mediated pathology.
 DT    9411
 AU    Eckwalanga M; Marussig M; Tavares MD; Bouanga JC; Hulier E; Pavlovitch
       JH; Minoprio P; Portnoi D; Renia L; Mazier D; Institut National de la
       Sante et de la Recherche Medicale,; Unite 313, Departement de
       Parasitologie, Paris, France.
 SO    Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8097-101. Unique Identifier
       : AIDSLINE MED/94336693
 AB    The retrovirus LP-BM5 murine leukemia virus induces murine AIDS in
       C57BL/6 mice that has many similarities with human AIDS; Plasmodium
       berghei ANKA causes experimental cerebral malaria in the same strain of
       mice. The outcome of malaria infection was studied in mice concurrently
       infected with the two pathogens. The retrovirus significantly reduced
       the gravity of the neurological manifestations associated with
       Plasmodium berghei ANKA infection. The protection against experimental
       cerebral malaria induced by murine AIDS increased with duration of viral
       infection and, hence, with the severity of the immunodeficiency.
       Interleukin 10, principally from splenic T cells, was shown to play a
       crucial role in this protection.
 DE    Animal  Antigens, CD4/*ANALYSIS  Base Sequence  Comparative Study
       Defective Viruses/ISOLATION & PURIF  DNA Primers  Female  Genome, Viral
       Human  Interleukin-10/*PHARMACOLOGY  *Leukemia Viruses, Murine/ISOLATION
       & PURIF  *Lymphocyte Transformation  Malaria,
       Cerebral/IMMUNOLOGY/PATHOLOGY/*PREVENTION & CONTROL  Mice  Mice, Inbred
       C57BL  Molecular Sequence Data  Murine Acquired Immunodeficiency
       Syndrome/IMMUNOLOGY/PATHOLOGY/  *PHYSIOPATHOLOGY  *Plasmodium berghei
       Polymerase Chain Reaction  Support, Non-U.S. Gov't  T-Lymphocytes,
       Helper-Inducer/DRUG EFFECTS/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).