Document 0377
 DOCN  M9490377
 TI    Proposal for experimental studies to evaluate sodium hypochlorite
       dialysate in retroviral treatment.
 DT    9411
 AU    Avlicino AA; Newton CL
 SO    Med Hypotheses. 1994 Mar;42(3):169-72. Unique Identifier : AIDSLINE
       MED/94335771
 AB    Sodium hypochlorite (NaOCl) is widely used to inactivate retroviruses
       topically and on environmental surfaces. This proposal establishes the
       thesis that sodium hypochlorite and its related oxygen free radicals can
       be administered in minute quantities in vivo to achieve a reduction in
       retroviral titer within the infected individual. Published reports of
       animal studies and accidental sodium hypochlorite infusion in much
       greater concentrations have indicated that the protein depletion and
       oxidation of sulfhydryl compounds is reversible and possibly preventable
       by administration of disulfide reducing agents. Various methods of
       infusion can include the ex vivo retroviral inactivation of plasma
       utilizing extracorporeal circulation through a continuous centrifugal
       plasma separator. The utilization of infusion of low-concentration
       sodium hypochlorite dialysate for retroviral inactivation merits
       immediate experimental study. Chlorinated tap-water and table salt
       ingestion must also be among the environmental factors studied for
       correlation to HIV infection.
 DE    Animal  Disinfectants/ADMINISTRATION & DOSAGE  Human  HIV
       Infections/DRUG THERAPY  Infusions, Parenteral  Models, Biological
       Proteins/METABOLISM  Reactive Oxygen Species/METABOLISM  Retroviridae
       Infections/*DRUG THERAPY  Sodium Hypochlorite/*ADMINISTRATION & DOSAGE
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).