Document 0378
 DOCN  M9490378
 TI    Direct involvement of extracellular HIV-1 virions in the apoptosis of
       CD8+ lymphocytes: a two-step model.
 DT    9411
 AU    Mercure L; Wainberg MA; McGill University AIDS Centre, Lady Davis
       Institute--Jewish; General Hospital, Montreal, Quebec, Canada.
 SO    Med Hypotheses. 1994 Mar;42(3):159-68. Unique Identifier : AIDSLINE
       MED/94335770
 AB    Lymphocytes of the CD8 phenotype play an important role in controlling
       viral burden in HIV-1 infection. Cytotoxic CD8+ T lymphocytes (CTL) can
       kill HIV-infected cells and in addition, are able to secrete a soluble
       factor that inhibits HIV replication. In most cases, HIV-infected
       individuals experience an unexplained CD8+ lymphopenia during the
       advanced stage of the disease that particularly affect HIV-1-specific
       CTL. It has been reported that CD8+ lymphocytes in HIV-infected
       individuals undergo programmed cell death or apoptosis. We now present a
       two-step model to explain CD8+ apoptosis, based on anchorage of
       HIV-1-associated MHC class 1 antigen into the envelope of extracellular
       viral particles.
 DE    Antigens, CD8  Apoptosis  Histocompatibility Antigens Class I  Human
       HIV Infections/BLOOD/ETIOLOGY  HIV-1/IMMUNOLOGY/*PHYSIOLOGY
       Lymphopenia/ETIOLOGY  *Models, Biological  Receptors, Antigen, T-Cell
       T-Lymphocytes, Cytotoxic/IMMUNOLOGY/*PATHOLOGY  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

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