Document 0383
 DOCN  M9490383
 TI    The model of arthritis induced by superantigen in mice.
 DT    9411
 AU    Nagai H; Takaoka Y; Kamada H; Mori H; Department of Pharmacology, Gifu
       Pharamaceutical University,; Japan.
 SO    Life Sci. 1994;55(12):PL233-7. Unique Identifier : AIDSLINE MED/94335520
 AB    Subcutaneous injection of Staphylococcal enterotoxin B (SEB) produced by
       Staphylococcus aureus, caused severe arthritis in DBA/1J mice which had
       been previously immunized with bovine type II collagen. The severity of
       this arthritis was dose dependent and prolonged joint inflammation with
       erosion of bone was observed. Anti- type II collage antibodies were
       detected in the serum of arthritic mice. Effector T cells against type
       II collagen were also detected by means of delayed type hypersensitivity
       in the skin. Moreover, a significant decrease in the ratio between T
       cells and B cells and an increase in the ratio between CD4+ cells and
       CD8+ cells was observed in spleen cells from arthritic mice.
       Prednisolone suppresses the induction and development of clinical signs
       of arthritis in mice. This evidence suggests that this experimental
       arthritis model may provide a means to examine the role of superantigens
       and the efficacy of pharmacological agents for the treatment of
       rheumatoid arthritis.
 DE    Animal  Antibodies/BLOOD  Arthritis/DRUG
       THERAPY/*ETIOLOGY/IMMUNOLOGY/PATHOLOGY  B-Lymphocytes/IMMUNOLOGY
       Collagen/IMMUNOLOGY  CD4-CD8 Ratio  *Disease Models, Animal
       Dose-Response Relationship, Drug  *Enterotoxins  Hypersensitivity,
       Delayed  Immunity, Cellular  Male  Mice  *Mice, Inbred DBA
       Prednisolone/THERAPEUTIC USE  Spleen/CYTOLOGY/IMMUNOLOGY  Staphylococcus
       aureus/*IMMUNOLOGY  *Superantigens  T-Lymphocytes/IMMUNOLOGY  JOURNAL
       ARTICLE

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