Document 0394
 DOCN  M9490394
 TI    Serodiagnosis of Penicillium marneffei infection.
 DT    9411
 AU    Yuen KY; Wong SS; Tsang DN; Chau PY; Department of Microbiology, Queen
       Mary Hospital, University of; Hong Kong.
 SO    Lancet. 1994 Aug 13;344(8920):444-5. Unique Identifier : AIDSLINE
       MED/94335405
 AB    Diagnosis of Penicillium marneffei infection is often made late. We
       evaluated an indirect immunofluorescent antibody test for P marneffei in
       serum from 103 patients with persistent fever and from 78 normal
       subjects. Germinating conidia (initial tissue-invasion phase) and
       yeast-hyphae (tissue multiplication phase) forms were used as antigen.
       All 8 documented P marneffei cases (8%) had an IgG titre of 160 or more;
       the other 95 patients and all the healthy controls had an IgG titre of
       40 or below. Blood culture was positive in only 1 case with HIV
       infection. Biopsy and culture of tissues were necessary for confirmation
       in the other 7 cases. The test could provide rapid presumptive diagnosis
       and supplement conventional culture.
 DE    Antibodies, Fungal/*BLOOD  Biopsy  Case-Control Studies  Cross Reactions
       *Fluorescent Antibody Technique  Human
       Mycoses/BLOOD/*DIAGNOSIS/EPIDEMIOLOGY  Penicillium/*CLASSIFICATION
       Sensitivity and Specificity  Serodiagnosis  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

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