Document 0398
 DOCN  M9490398
 TI    Isolation and characterization of human immunodeficiency virus type 1
       variants infectious to brain-derived cells: detection of common point
       mutations in the V3 region of the env gene of the variants.
 DT    9411
 AU    Shimizu NS; Shimizu NG; Takeuchi Y; Hoshino H; Department of Hygiene and
       Virology, Gunma University School of; Medicine, Japan.
 SO    J Virol. 1994 Sep;68(9):6130-5. Unique Identifier : AIDSLINE
       GENBANK/D34611
 AB    T-cell-line-tropic human immunodeficiency virus type 1 cannot infect
       CD4-positive, brain-derived cells. We isolated several new variants that
       readily infected brain-derived cells. Mutation of proline to serine, to
       alanine, or to threonine in the well-conserved GPGR sequence in the V3
       region of the envelope glycoprotein was found in all these variants.
       This indicates the importance of amino acid sequences at the tip of the
       V3 region for brain cell tropism of human immunodeficiency virus type 1.
 DE    Amino Acid Sequence  Base Sequence  Brain/*MICROBIOLOGY  Cells, Cultured
       Comparative Study  DNA Primers/CHEMISTRY  Genes, env  Human  HIV
       Envelope Protein gp120/*GENETICS  HIV-1/*PATHOGENICITY  In Vitro
       Molecular Sequence Data  Sequence Alignment  Sequence Homology, Amino
       Acid  Sequence Homology, Nucleic Acid  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE

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