Document 0399
 DOCN  M9490399
 TI    Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with
       control of viremia in primary human immunodeficiency virus type 1
       infection.
 DT    9411
 AU    Borrow P; Lewicki H; Hahn BH; Shaw GM; Oldstone MB; Department of
       Neuropharmacology, Scripps Research Institute, La; Jolla, California
       92037.
 SO    J Virol. 1994 Sep;68(9):6103-10. Unique Identifier : AIDSLINE
       MED/94335134
 AB    Human immunodeficiency virus type 1 (HIV-1) Env-, Gag-, Pol-, Nef-, and
       Tat-specific cytotoxic T-lymphocyte (CTL) activities were quantitated
       temporally in five patients with symptomatic primary HIV-1 infection. A
       dominant CD8(+)-mediated, major histocompatibility complex class
       I-restricted CTL response to the HIV-1 envelope glycoprotein, gp160, was
       noted in four of the five patients studied. The level of HIV-1-specific
       CTL activity in the five patients paralleled the efficiency of control
       of primary viremia. Patients who mounted strong gp160-specific CTL
       responses showed rapid reduction of acute plasma viremia and
       antigenemia, while in contrast, primary viremia and antigenemia were
       poorly controlled in patients in whom virus-specific CTL activity was
       low or undetectable. These results suggest that HIV-1-specific CTL
       activity is a major component of the host immune response associated
       with the control of virus replication following primary HIV-1 infection
       and have important implications for the design of antiviral vaccines.
 DE    Amino Acid Sequence  Gene Products, env/*IMMUNOLOGY  Human  HIV
       Antigens/IMMUNOLOGY  HIV Infections/*IMMUNOLOGY  HIV-1/*IMMUNOLOGY
       Molecular Sequence Data  Peptides/IMMUNOLOGY  Protein
       Precursors/*IMMUNOLOGY  Support, U.S. Gov't, Non-P.H.S.  Support, U.S.
       Gov't, P.H.S.  T-Lymphocyte Subsets/*IMMUNOLOGY  T-Lymphocytes,
       Cytotoxic/*IMMUNOLOGY  Viremia/MICROBIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).