Document 0400
 DOCN  M9490400
 TI    The sequences of and distance between two cis-acting signals determine
       the efficiency of ribosomal frameshifting in human immunodeficiency
       virus type 1 and human T-cell leukemia virus type II in vivo.
 DT    9411
 AU    Kollmus H; Honigman A; Panet A; Hauser H; Gesellschaft fur
       Biotechnologische Forschung mbH, Braunschweig,; Federal Republic of
       Germany.
 SO    J Virol. 1994 Sep;68(9):6087-91. Unique Identifier : AIDSLINE
       MED/94335131
 AB    We have analyzed in cell culture the sequence elements that control the
       level of ribosomal frameshifting in the human T-cell leukemia virus type
       II (HTLV-2) gag-pro junction. The slippery sequence of HTLV-2 is
       sufficient to dictate a basal level of frameshifting. This level is
       enhanced by its upstream sequence context and by the downstream
       stem-loop structure which is located at an optimal distance of 7 bases.
       Frameshifting in human immunodeficiency virus gag-pol is similar to that
       of HTLV-2 gag-pro. However, experiments using hybrid cassettes of HTLV-2
       and human immunodeficiency virus type 1 frameshift elements show that
       while the slippery sequence of HTLV-2 is less efficient, the stem-loop
       structure is a more efficient enhancer.
 DE    Base Sequence  *Gene Expression Regulation, Viral  Genes, gag  Genes,
       Structural, Viral  Hydrogen Bonding  HIV-1/*GENETICS  HTLV-II/*GENETICS
       Molecular Sequence Data  Nucleic Acid Conformation  Regulatory
       Sequences, Nucleic Acid  Ribosomes/METABOLISM  Structure-Activity
       Relationship  Support, Non-U.S. Gov't  Translation, Genetic  JOURNAL
       ARTICLE

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