Document 0415
 DOCN  M9490415
 TI    Murine AIDS is an antigen-driven disease: requirements for major
       histocompatibility complex class II expression and CD4+ T cells.
 DT    9411
 AU    Giese NA; Giese T; Morse HC 3rd; Laboratory of Immunopathology, National
       Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892.
 SO    J Virol. 1994 Sep;68(9):5819-24. Unique Identifier : AIDSLINE
       MED/94335098
 AB    Murine AIDS (MAIDS) is a complex syndrome of lymphoproliferation and
       immunodeficiency induced by a replication-defective murine leukemia
       virus (BM5def) that encodes Pr60gag as its only product. It has been
       suggested that the gag polyprotein is responsible for vigorous antigenic
       stimulation of CD4+ T cells and generalized secondary activation of the
       immune system. This model was tested first by infecting mice (C2K/O)
       that lack class II major histocompatibility complex molecules required
       for presentation of antigens to CD4+ T cells. C2K/O mice expressed
       BM5def at high levels but did not develop MAIDS either when
       unmanipulated or following transfer of CD4+ T cells. Second, B6 mice
       reconstituted with C2K/O bone marrow cells had normal frequencies of B
       cells (class II negative) and CD4+ cells and expressed high levels of
       BM5def transcripts but did not develop MAIDS; however, MAIDS developed
       in class II-competent nu/nu mice reconstituted with CD4+ T cells and in
       C2K/O mice reconstituted with B6 bone marrow to give class II-positive B
       cells and with purified CD4+ T cells. These results indicate that
       induction of MAIDS by BM5def is antigen driven and is dependent on
       expression of major histocompatibility complex class II molecules on
       antigen-presenting cells and the presence of CD4+ T cells.
 DE    Animal  Antigens, Surface/ANALYSIS  Base Sequence  DNA Primers/CHEMISTRY
       Histocompatibility Antigens Class II/*IMMUNOLOGY  Leukemia Viruses,
       Murine/GROWTH & DEVELOPMENT/IMMUNOLOGY/  *PATHOGENICITY  Lymphocyte
       Transformation  Membrane Glycoproteins/ANALYSIS  Mice  Mice, Inbred
       C57BL  Mice, Nude  Molecular Sequence Data  Murine Acquired
       Immunodeficiency Syndrome/*IMMUNOLOGY  Mutagenesis, Site-Directed
       Structure-Activity Relationship  Support, Non-U.S. Gov't  Support, U.S.
       Gov't, P.H.S.  T-Lymphocyte Subsets/IMMUNOLOGY  T4
       Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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