Document 0422
 DOCN  M9490422
 TI    The p15gag and p12gag regions are both necessary for the pathogenicity
       of the murine AIDS virus.
 DT    9411
 AU    Kubo Y; Kakimi K; Higo K; Wang L; Kobayashi H; Kuribayashi K; Masuda T;
       Hirama T; Ishimoto A; Department of Viral Oncology, Kyoto University,
       Japan.
 SO    J Virol. 1994 Sep;68(9):5532-7. Unique Identifier : AIDSLINE
       MED/94335065
 AB    The defective murine AIDS (MAIDS) virus has unique sequences in its
       p15gag and p12gag regions. To clarify whether these sequences are
       responsible for the development of MAIDS, we constructed recombinant
       viruses by replacing various regions of the gag gene of the
       nonpathogenic replication-competent LP-BM5 ecotropic virus with those of
       the MAIDS virus. Recombinants containing both unique sequences of the
       MAIDS virus were replication defective and induced MAIDS. However, a
       recombinant containing either the p15gag or p12gag region of the MAIDS
       virus was also replication defective but nonpathogenic in mice. A
       recombinant virus containing only the p30gag region of the MAIDS virus
       was replication competent and nonpathogenic. These results indicate that
       the p15gag and p12gag regions of the MAIDS virus do not function like
       those of replication-competent viruses and that both of the unique
       sequences in the p15gag and p12gag regions are required to develop
       MAIDS.
 DE    Animal  Chimeric Proteins  Gene Products, gag/*PHYSIOLOGY  Leukemia
       Viruses, Murine/*PATHOGENICITY  Mice  Mice, Inbred C57BL  Murine
       Acquired Immunodeficiency Syndrome/*MICROBIOLOGY  Support, Non-U.S.
       Gov't  Support, U.S. Gov't, P.H.S.  Virus Replication  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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