Document 0434
 DOCN  M9490434
 TI    Structure-based design of HIV-1 protease inhibitors: replacement of two
       amides and a 10 pi-aromatic system by a fused bis-tetrahydrofuran.
 DT    9411
 AU    Ghosh AK; Thompson WJ; Fitzgerald PM; Culberson JC; Axel MG; McKee SP;
       Huff JR; Anderson PS; Department of Medicinal Chemistry, Merck Research
       Laboratories,; West Point, Pennsylvania 19486.
 SO    J Med Chem. 1994 Aug 5;37(16):2506-8. Unique Identifier : AIDSLINE
       MED/94334906
 DE    Crystallography, X-Ray  *Drug Design
       Furans/*CHEMISTRY/METABOLISM/PHARMACOLOGY  Hydrogen Bonding  HIV
       Protease/METABOLISM  HIV Protease Inhibitors/*CHEMISTRY/METABOLISM
       HIV-1/DRUG EFFECTS/*ENZYMOLOGY
       Isoquinolines/CHEMISTRY/METABOLISM/PHARMACOLOGY  Models, Molecular
       Molecular Structure  Quinolines/CHEMISTRY/METABOLISM  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).