Document 0440
 DOCN  M9490440
 TI    Malignant lymphoma associated with experimentally induced feline
       immunodeficiency virus infection.
 DT    9411
 AU    Poli A; Abramo F; Baldinotti F; Pistello M; Da Prato L; Bendinelli M;
       Department of Animal Pathology, University of Pisa, Italy.
 SO    J Comp Pathol. 1994 May;110(4):319-28. Unique Identifier : AIDSLINE
       MED/94334417
 AB    A malignant low-grade B-cell lymphoma, primarily in the kidney, is
       described in a specific-pathogen-free cat experimentally infected with
       feline immunodeficiency virus (FIV) and free of feline leukaemia virus.
       At the time of diagnosis the cat showed a marked reduction of
       circulating CD4+ T lymphocytes, was 2 years old, and had been infected
       for 18 months. FIV was isolated both from peripheral blood mononuclear
       cells and the neoplastic tissue. DNA of FIV gag gene was detected in
       several specimens, including the neoplastic tissue. Even if they do not
       demonstrate a direct role for virus promotion of lymphomas, these and
       previous observations indicate that B-cell malignant lymphoma might be
       associated with FIV infection as reported for human and simian
       immunodeficiency virus infections.
 DE    Animal  Blood Cell Count  Bone Marrow/PATHOLOGY  Cats  Feline Acquired
       Immunodeficiency Syndrome/*COMPLICATIONS/
       IMMUNOLOGY/MICROBIOLOGY/PATHOLOGY  Female  Immunodeficiency Virus,
       Feline/ISOLATION & PURIF  Immunoglobulins/ANALYSIS  Immunohistochemistry
       Kidney/PATHOLOGY  Leukocyte Count  Lymph Nodes/PATHOLOGY  Lymphoma,
       B-Cell/*COMPLICATIONS/MICROBIOLOGY/PATHOLOGY  Microscopy, Electron
       Specific Pathogen-Free Organisms  Spleen/PATHOLOGY  Support, Non-U.S.
       Gov't  T4 Lymphocytes  JOURNAL ARTICLE

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       protected by Copyright Law (Title 17, U.S.Code).