Document 0448
 DOCN  M9490448
 TI    The mating-type region of Schizosaccharomyces pombe contains an
       essential gene encoding a protein homologous to human modulators of HIV
       transactivation.
 DT    9411
 AU    Michael H; Schmidt H; Fleck O; Gutz H; Liedtke C; Lorentz A; Ostermann
       K; Institut fur Genetik, Technische Universitat Braunschweig,; Germany.
 SO    Gene. 1994 Aug 5;145(2):205-10. Unique Identifier : AIDSLINE
       GENBANK/U02280
 AB    In Schizosaccharomyces pombe, an intrachromosomal crossover between the
       mating type (MT) expression locus and one of the silent donor cassettes
       is lethal due to the loss of the intervening L region. The region
       contains one essential gene, let1. This gene was cloned and sequenced.
       The deduced amino acid (aa) sequence of let1 shows extensive homologies
       with SUG1 from Saccharomyces cerevisiae. Significant homologies were
       also found with the human HIV transactivation modulators, MSS1 and
       TBP-1, as well as with subunit 4 of the mammalian 26 S protease. The
       data indicate that let1 is a member of a recently defined multigene
       family of ATPases.
 DE    Adenosinetriphosphatase/CLASSIFICATION/*GENETICS  Amino Acid Sequence
       Base Sequence  Cloning, Molecular  Comparative Study  Fungal
       Proteins/*GENETICS  Genes, Fungal/*GENETICS  Genes, Lethal/*GENETICS
       Human  HIV/GENETICS  Molecular Sequence Data  Peptides/GENETICS
       Schizosaccharomyces/*GENETICS  Sequence Analysis, DNA  Sequence
       Homology, Amino Acid  Support, Non-U.S. Gov't  Trans-Activation
       (Genetics)  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).