Document 0454
 DOCN  M9490454
 TI    Serum immunoglobulin profiles in asymptomatic HIV-1 seropositive adults
       and in patients with AIDS in Dar es Salaam, Tanzania.
 DT    9411
 AU    Lyamuya EF; Maselle SY; Matre R; Department of Microbiology and
       Immunology, Muhimbili University; College of Health Sciences, Dar es
       Salaam, Tanzania.
 SO    East Afr Med J. 1994 Jan;71(1):24-8. Unique Identifier : AIDSLINE
       MED/94333129
 AB    Serum levels of immunoglobulin classes and IgG subclasses were
       determined in healthy seronegative (n = 50) and in HIV-1 seropositive
       adults (n = 50) from Tanzania, a region with heterosexual HIV-1
       transmission pattern. The mean levels of total IgG, IgG1, IgG3, IgA,
       IgM, and IgD obtained were found to be significantly higher in HIV-1
       seropositive sera than in control sera. The mean IgA, IgM, IgD and IgG3
       levels showed an increasing trend with progression from asymptomatic
       phase to AIDS phase. The mean levels for total IgG, IgG1 and IgG2
       remained constant while that for IgG4 decreased with progression to AIDS
       phase. From the findings, it is concluded that polyisotypic
       hypergammaglobulinaemia and serum IgG subclass changes occur in HIV-1
       seropositive individuals in Tanzania. The characteristic changes
       observed for IgD, IgG3 and IgG4 levels with evolution from asymptomatic
       to AIDS phases could be of value in monitoring disease progression.
 DE    Acquired Immunodeficiency Syndrome/*BLOOD/COMPLICATIONS/
       EPIDEMIOLOGY/TRANSMISSION  Adult  Case-Control Studies  Human
       Hypergammaglobulinemia/ETIOLOGY  HIV
       Seropositivity/*BLOOD/COMPLICATIONS/EPIDEMIOLOGY/TRANSMISSION  *HIV-1
       Immunoglobulin Isotypes/*BLOOD/CLASSIFICATION  Matched-Pair Analysis
       *Population Surveillance  Seroepidemiologic Methods  Sex Behavior
       Support, Non-U.S. Gov't  Tanzania/EPIDEMIOLOGY  Urban Population
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).