Document 0463
 DOCN  M9490463
 TI    Successful treatment of a patient with seropositive human
       immunodeficiency virus with high risk Burkitt's leukemia.
 DT    9411
 AU    Greenberg AL; Droller DG; Department of Medicine, University of Miami
       School of Medicine,; Florida.
 SO    Cancer. 1994 Aug 15;74(4):1261-4. Unique Identifier : AIDSLINE
       MED/94332776
 AB    A 24-year-old male patient seropositive for the human immunodeficiency
       virus with Burkitt's Leukemia was treated successfully with aggressive
       systemic chemotherapy and central nervous system prophylaxis. He
       presented with a leukocyte count of 68,900/microliter with 33% L3
       lymphoblasts, massive hepatosplenomegaly, generalized lymphadenopathy, a
       lactic dehydrogenase level of 9105 IU/l, creatinine level of 5.8 mg/dl,
       and a uric acid level of 43.5 mg/dl. Hemodialysis, intrathecal
       methotrexate, hydrocortisone and cytosine arabinoside, and fractionated
       doses of cyclophosphamide followed by vincristine and doxorubicin were
       promptly instituted. He received eight subsequent courses of
       chemotherapy consisting of either methotrexate with leucovorin rescue
       and high dose, continuous infusion cytosine arabinoside or
       cyclophosphamide, vincristine, and methotrexate with leucovorin. There
       was marked hematologic toxicity resulting from this treatment. However,
       the patient was alive and in complete remission more than 6 years from
       diagnosis. This paper demonstrated that it is possible to successfully
       treat a patient who is HIV-1 antibody positive with poor prognosis
       Burkitt's Leukemia. Further studies need to be undertaken to define the
       least toxic, most effective therapy for this disease.
 DE    Adult  Antineoplastic Agents, Combined/ADMINISTRATION & DOSAGE/
       *THERAPEUTIC USE  Case Report  Combined Modality Therapy
       Cyclophosphamide/ADMINISTRATION & DOSAGE  Cytarabine/ADMINISTRATION &
       DOSAGE  Doxorubicin/ADMINISTRATION & DOSAGE  Hemodialysis  Human
       Hydrocortisone/ADMINISTRATION & DOSAGE  HIV
       Seropositivity/*COMPLICATIONS  Injections, Intravenous  Injections,
       Spinal  Leukemia, B-Cell, Acute/*COMPLICATIONS/*DRUG THERAPY  Male
       Methotrexate/ADMINISTRATION & DOSAGE  Remission Induction
       Vincristine/ADMINISTRATION & DOSAGE  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).