Document 0468 DOCN M9490468 TI Viral interactions with the host-cell cytoskeleton: the role of retroviral proteases. DT 9411 AU Luftig RB; Lupo LD; Dept of Microbiology, Immunology and Parasitology, Louisiana; State University Medical Center, New Orleans 70112-1393. SO Trends Microbiol. 1994 May;2(5):178-82. Unique Identifier : AIDSLINE MED/94332444 AB A surprisingly large number of animal viruses interact with cytoskeletal elements inside infected cells at different stages of replication. For example, a viral protease is activated during assembly of murine leukemia viruses at the cell surface, which causes both the morphological conversion of 'immature' to 'mature' particles and a drastic reduction of the actin stress fiber network. DE Animal Cytoskeleton/*METABOLISM Human HIV/ENZYMOLOGY HIV Protease/*PHYSIOLOGY Leukemia Viruses, Murine/*ENZYMOLOGY/PHYSIOLOGY Models, Biological Peptide Peptidohydrolases/*PHYSIOLOGY Support, Non-U.S. Gov't Virus Replication/PHYSIOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL SOURCE: National Library of Medicine. NOTICE: This material may be protected by Copyright Law (Title 17, U.S.Code).