Document 0474
 DOCN  M9490474
 TI    Successful bone marrow transplantation in a boy with X-linked
       lymphoproliferative syndrome and acute severe infectious mononucleosis.
 DT    9411
 AU    Pracher E; Panzer-Grumayer ER; Zoubek A; Peters C; Gadner H; St. Anna
       Children's Hospital, Vienna, Austria.
 SO    Bone Marrow Transplant. 1994 May;13(5):655-8. Unique Identifier :
       AIDSLINE MED/94332079
 AB    We report a 5.9-year-old boy with X-linked lymphoproliferative syndrome
       (XLP) who presented with acute severe infectious mononucleosis. Clinical
       symptoms rapidly improved after chemotherapy with etoposide. Allogeneic
       bone marrow transplantation (BMT) was performed after conditioning with
       etoposide, busulfan and cyclophosphamide. After successful hematopoietic
       recovery we were able to demonstrate seroconversion from an impaired
       antibody response to Epstein-Barr virus (EBV) to a normal
       antibody-producing state in an immunocompetent child. The only
       post-transplant complication was mild acute graft-versus-host disease
       (GVHD). Three years after BMT, the boy is healthy and shows no signs of
       immunodeficiency. This is the first report on successful allogeneic BMT
       in the severe course of acute infectious mononucleosis in a patient with
       XLP. We speculate that the application of etoposide contributed to the
       positive outcome in this patient.
 DE    Acute Disease  *Bone Marrow Transplantation  Case Report  Child,
       Preschool  Etoposide/THERAPEUTIC USE  Human  Infectious
       Mononucleosis/*THERAPY  *Linkage (Genetics)  Lymphoproliferative
       Disorders/GENETICS/*THERAPY  Male  Transplantation, Homologous  *X
       Chromosome  JOURNAL ARTICLE

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