Document 0475
 DOCN  M9490475
 TI    [Clinical and prognostic significance of cellular immunity factors in
       patients with chronic liver diseases]
 DT    9411
 AU    Podymova SD; Rachvelishvili NB
 SO    Vestn Ross Akad Med Nauk. 1994;(5):14-8. Unique Identifier : AIDSLINE
       MED/94332010
 AB    The paper presents the results of comprehensive studies of quantitative
       and functional parameters of cellular immunity in 283 patients with
       chronic liver diseases, using various rosette tests and monoclonal
       antibody phenotyping of immunocompetent cells. The pattern of changes in
       blood immunocompetent cells and immunoglobulins allows prediction of the
       natural history of chronic active hepatitis and hepatic cirrhosis of
       viral and alcoholic origin. The data on autorosette-forming and
       hepatic-specific lipoprotein-sensitive rosette-forming cells were found
       to be the most informative. As compared to health, there were
       substantial changes in the subpopulation composition of immunocompetent
       cells and immunoglobulins in hepatic cirrhosis. The changes in
       immunoregulatory theophylline-resistant (OKT4+, OKT8+, T mu and T gamma)
       and theophylline-sensitive E-rosetting, as well as effector (ICO11+ and
       ICOHM1+) cells were the leading immunopathogenetic link of hepatic
       cirrhosis. In the latter, the subpopulation composition of
       immunocompetent cells depended on the activity of a pathological
       process, the state of compensation, as well as the levels of HBsAg and
       blood anti-delta-antibodies. The subpopulation analysis of
       immunocompetent cells enabled the author to outline the specific
       features of the immune status of etiological types, as well as
       predictive types of chronic active hepatitis and hepatic cirrhosis,
       which may serve as evidence for goal-oriented immunomodulating therapy.
 DE    Adolescence  Adult  Aged  Antibodies, Monoclonal  Biological
       Markers/BLOOD  CD4-CD8 Ratio  English Abstract  Female  Hepatitis
       B/*IMMUNOLOGY  Hepatitis B Surface Antigens/*BLOOD  Hepatitis, Chronic
       Active/*IMMUNOLOGY  Human  Immunocompetence  Immunoglobulins/*BLOOD
       Liver Cirrhosis, Alcoholic/*IMMUNOLOGY  Male  Middle Age  Phenotype
       Prognosis  Rosette Formation  T-Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

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