Document 0477
 DOCN  M9490477
 TI    On the antigenic diversity threshold model for AIDS.
 DT    9411
 AU    Stilianakis NI; Schenzle D; Dietz K; Department of Medical Biometry,
       University of Tubingen, Germany.
 SO    Math Biosci. 1994 Jun;121(2):235-47. Unique Identifier : AIDSLINE
       MED/94331887
 AB    In this paper stochastic simulations of a model for AIDS pathogenesis
       developed by Nowak and coworkers are presented. The results reveal a
       strong dependency on initial conditions, and the model predicts a
       nonmonotonic hazard rate for the transition to AIDS. Doubts are raised
       concerning the significance of the antigenic diversity threshold, since
       it only partially characterizes the model dynamics.
 DE    Acquired Immunodeficiency Syndrome/*ETIOLOGY  Antigenic Variation  Human
       HIV/IMMUNOLOGY  Mathematics  *Models, Biological  Stochastic Processes
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Time Factors
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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