Document 0480
 DOCN  M9490480
 TI    Sarcoma viruses containing the mos oncogene induce lesions resembling
       Kaposi's sarcoma.
 DT    9411
 AU    Stoica G; Department of Veterinary Pathobiology, College of Veterinary;
       Medicine, Texas A and M University, College Station 77843.
 SO    In Vivo. 1994 Jan-Feb;8(1):43-7. Unique Identifier : AIDSLINE
       MED/94331589
 AB    Kaposi's sarcoma is most accurately described as a multifocal
       angioproliferative lesion primarily involving the skin, although some
       studies indicated concomitant and/or exclusive visceral involvement. The
       mechanism(s) involved in Kaposi's sarcoma development, especially AIDS
       multiorgan distributed form, is not completely understood. Recent
       reports have identified a murine retrovirus, MoMuSV-349 that induces
       multiorgan disseminated angiosarcomatous tumors which resemble Kaposi's
       sarcoma when virus is inoculated intraperitoneally in newborn BALB/c
       mice. Performed time point experiment on mice infected with MoMuSV-349
       indicated a two stages development of Kaposi's sarcoma-like tumors;
       sarcomatous and angiosarcomatous. Preliminary studies have demonstrated
       the pathogenesis of the disease process and the role of angiogenic
       growth factors released by the spindled cells in the stage development
       of mouse tumors. It is hypothesized that growth factors such as
       fibroblast growth factors released by the spindled cells stimulate the
       proliferation of endothelial cells and neovascularization which is an
       essential component of Kaposi's sarcoma-like tumors. Understanding the
       mechanism(s) of endothelial cells proliferation and neovascularization
       as a response to viral insult and microenvironmental changes will raise
       the possibilities of developing new therapeutic approaches to block this
       process.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS  Animal  *Cell
       Transformation, Neoplastic  Comparative Study  *Genes, mos  Human  Mice
       Mice, Inbred BALB C  Moloney Sarcoma Virus/GENETICS/*PATHOGENICITY
       Retroviridae Infections/*PATHOLOGY  Sarcoma, Experimental/*PATHOLOGY
       Sarcoma, Kaposi's/ETIOLOGY/*PATHOLOGY  Tumor Virus Infections/*PATHOLOGY
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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