Document 0488
 DOCN  M9490488
 TI    Ablation of neoplasia by direct current.
 DT    9411
 AU    Taylor TV; Engler P; Pullan BR; Holt S; Baylor College of Medicine,
       Houston, Texas.
 SO    Br J Cancer. 1994 Aug;70(2):342-5. Unique Identifier : AIDSLINE
       MED/94331325
 AB    The application of low-voltage direct electrical current (DEC) has been
       studied in animals and humans for the ablation of anal condylomata,
       oesophageal cancer and Kaposi's sarcoma. Twenty milliamps of DEC passed
       through multiple 6 cm x 1 cm, flat-plate longitudinal electrodes into
       the squamous mucosa of the oesophagus of healthy dogs for periods
       ranging from 10 min to 2 h resulted in denudation and necrosis of the
       oesophageal mucosa at the site of application of the current. In humans,
       the application of DEC to two patients with benign anal condyloma
       acuminata, three patients with inoperable obstructing oesophageal cancer
       and one patient with disseminated Kaposi sarcoma resulted in striking
       necrosis of tumour tissue that was confirmed by macroscopic and
       microscopic studies. These initial findings imply promising therapeutic
       potential for the use of DEC as a simple, effective, safe, low-cost
       alternative for ablation of neoplasia.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/THERAPY
       Adenocarcinoma/THERAPY  Adult  Aged  Aged, 80 and over  Animal  Anus
       Diseases/THERAPY  Carcinoma, Squamous Cell/THERAPY  Case Report
       Condylomata Acuminata/THERAPY  Dogs  *Electric Stimulation Therapy
       Esophageal Neoplasms/THERAPY  Female  Human  Male  Middle Age
       Neoplasms/*THERAPY  Neoplasms, Experimental/*THERAPY  Sarcoma,
       Kaposi's/COMPLICATIONS/THERAPY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).