Document 0513
 DOCN  M9490513
 TI    Serum sickness-like illness associated with rifampicin.
 DT    9411
 AU    Parra FM; Perez Elias MJ; Cuevas M; Ferreira A; Servicio de Alergia,
       Hospital Ramon y Cajal, Madrid, Spain.
 SO    Ann Allergy. 1994 Aug;73(2):123-5. Unique Identifier : AIDSLINE
       MED/94346648
 AB    We describe a patient with human immunodeficiency virus infection who
       developed the main clinical features of a serum sickness reaction while
       receiving treatment with daily therapeutic doses of tuberculostatic
       drugs. A decrease in complement titers as well as a detection of
       significant levels of circulating immune complexes were observed. A
       positive skin test result was observed six hours after an intradermal
       test with rifampicin. No immunoglobulin or complement deposition was
       observed by direct immunofluorescence of a punch biopsy specimen from
       the cutaneous lesion.
 DE    Adult  Antigen-Antibody Complex/BLOOD  Biopsy  Case Report
       Complement/ANALYSIS  Dose-Response Relationship, Drug  Enzyme-Linked
       Immunosorbent Assay  Fluorescent Antibody Technique  Human  HIV
       Infections/BLOOD/DRUG THERAPY  Immunoglobulins/ANALYSIS  Male
       Rifampin/ADMINISTRATION & DOSAGE/*ADVERSE EFFECTS/THERAPEUTIC USE  Serum
       Sickness/*CHEMICALLY INDUCED  Skin/CHEMISTRY/PATHOLOGY  JOURNAL ARTICLE

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