Document 0527
 DOCN  M9490527
 TI    Pathogenic diversity of simian immunodeficiency viruses.
 DT    9411
 AU    Hirsch VM; Johnson PR; Immunodeficiency Viruses Section, NIAID, NIH,
       Rockville, MD; 20852.
 SO    Virus Res. 1994 May;32(2):183-203. Unique Identifier : AIDSLINE
       MED/94346053
 AB    The SIV family is a diverse group of viruses that vary considerably in
       pathogenesis and virulence in their natural host species or macaques.
       Although the disease induced by the SIVsm subtype in particular is
       remarkably similar to human AIDS, it must be remembered that this is an
       experimental animal model. Therefore, although the pathogenesis of SIVsm
       (and other viruses) in macaques offers an relevant animal model for
       pathogenesis and vaccine trials, the interactions of these viruses in
       their natural host, and virus-, or host-specific effects have been
       poorly characterized. This animal model offers a unique opportunity to
       study the details of the pathogenesis of immunodeficiency and to define
       host and viral factors responsible for disease progression.
 DE    Acquired Immunodeficiency Syndrome/ETIOLOGY  Animal  Disease Models,
       Animal  DNA, Viral/GENETICS  Human  Macaca  Phylogeny  Simian Acquired
       Immunodeficiency Syndrome/ETIOLOGY
       SIV/CLASSIFICATION/GENETICS/*PATHOGENICITY  Variation (Genetics)
       Virulence/GENETICS  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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