Document 0551
 DOCN  M9490551
 TI    [Bone sterilization by radiation and the HIV virus]
 DT    9411
 AU    Hernigou P; Marce D; Julieron A; Marinello G; Dormont D; Chirurgie
       Orthopedique, Hopital Henri Mondor, Creteil.
 SO    Rev Chir Orthop Reparatrice Appar Mot. 1993;79(6):445-51. Unique
       Identifier : AIDSLINE MED/94345209
 AB    An experimental study was performed to investigate the efficacy of
       irradiating HIV-contaminated allografts. Irradiation was achieved using
       an accelerator delivering 6.3 MeV electrons, and the viral strain was
       HIV-1/LAV-1. At an activity equivalent to 600.000 counts of reverse
       transcriptase activity per minute and per millilitre, irradiation
       permitted total inactivation of HIV. In the light of present data
       concerning plasma viremia in HIV-infected patients, this experiment
       suggested that irradiation minimizes as far as possible the risk of
       transmitting HIV infection through bone transplantation from a
       seronegative, contaminant donor. However, in view of the relative
       imprecision of viral sensitivity curves, irradiation does not authorize
       bone transplantation from a seropositive patient, even though the bone
       has been irradiated.
 DE    Animal  Bone Marrow Transplantation  *Bone Transplantation  Cells,
       Cultured  Dose-Response Relationship, Radiation  English Abstract  Human
       HIV Infections/*PREVENTION & CONTROL/TRANSMISSION
       HIV-1/PATHOGENICITY/*RADIATION EFFECTS  Lymphocytes/MICROBIOLOGY
       Radiotherapy, High-Energy/*METHODS  Sterilization/*METHODS
       Virulence/RADIATION EFFECTS  JOURNAL ARTICLE

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