Document 0573
 DOCN  M9490573
 TI    Olfactory mucosa response in guinea pigs following intranasal
       instillation with Cryptococcus neoformans. A histological and
       immunocytochemical study.
 DT    9411
 AU    Lima C; Vital JP; Laboratory of Experimental Microsurgery, Hospital Egas
       Moniz,; Lisbon, Portugal.
 SO    Mycopathologia. 1994 May;126(2):65-73. Unique Identifier : AIDSLINE
       MED/94344220
 AB    A central nervous system isolate from an acquired immunodeficiency
       syndrome (AIDS) patient of 10(3) Cryptococcus neoformans cells was
       instilled intranasally into guinea pigs. These were killed to evaluate
       the fate of the organisms and the response of the olfactory mucosa.
       Olfactory epithelium prevented the penetration of Cryptococcus
       neoformans and showed focal hyperplastic responses. The organisms, which
       manifested an affinity for the olfactory portion of the nasal cavities,
       were cleared from the olfactory space with no intervention from the
       immune system cells. By the end of the fifth week almost no organisms
       could be found and there was no histological evidence of dissemination.
       In contrast, destruction of the olfactory epithelium with zinc sulfate
       allowed the invasion of the subepithelial tissues, demonstrating the
       role of the olfactory mucosa in preventing infection with Cryptococcus
       neoformans through the nasal route. The results and the model described
       in this report may be useful in clarifying the pathogenic mechanisms of
       cryptococcosis and the non immune mediated host responses to
       Cryptococcus neoformans.
 DE    Adult  Animal  AIDS-Related Opportunistic Infections/CEREBROSPINAL
       FLUID/  MICROBIOLOGY  Case Report  Cryptococcosis/CEREBROSPINAL
       FLUID/MICROBIOLOGY  *Cryptococcus neoformans/ISOLATION & PURIF
       Epithelium/MICROBIOLOGY/PATHOLOGY/PHYSIOLOGY  Female  Guinea Pigs  Human
       Hyperplasia  Male  Olfactory Mucosa/MICROBIOLOGY/PATHOLOGY/*PHYSIOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).