Document 0605
 DOCN  M9490605
 TI    Olfactory pathways in three patients with cryptococcal meningitis and
       acquired immune deficiency syndrome.
 DT    9411
 AU    Lima C; Vital JP; Department of Neurology, Hospital Egas Moniz, Lisbon,
       Portugal.
 SO    J Neurol Sci. 1994 May;123(1-2):195-9. Unique Identifier : AIDSLINE
       MED/94342933
 AB    The olfactory mucosa, bulbs and tracts were examined for the presence of
       Cryptococcus neoformans in 3 patients with the acquired immune
       deficiency syndrome (AIDS) and cryptococcal meningitis. Two of them had
       antibodies against HIV-1 and one had positive serology for HIV-2.
       Cryptococci were seen in the subarachnoid space around olfactory tracts
       and bulbs and in the submucosal olfactory nerve fascicles. In one case,
       olfactory nerve fascicles from the lamina propria were also affected.
       Olfactory epithelium and respiratory mucosa were not involved. We
       suggest that Cryptococcus reached the olfactory nerve fascicles through
       the olfactory pathways for cerebrospinal fluid drainage which might
       serve as a source of latent cryptococcal infection.
 DE    Adult  AIDS-Related Opportunistic Infections/*PATHOLOGY  Case Report
       Cryptococcus neoformans/ISOLATION & PURIF  Human  HIV
       Antibodies/ANALYSIS  HIV-1  HIV-2  Male  Meningitis,
       Cryptococcal/ETIOLOGY/*PATHOLOGY  Middle Age  Olfactory
       Bulb/MICROBIOLOGY/*PATHOLOGY  Olfactory Mucosa/MICROBIOLOGY/PATHOLOGY
       Olfactory Nerve/MICROBIOLOGY/*PATHOLOGY  Olfactory
       Pathways/MICROBIOLOGY/*PATHOLOGY  Subarachnoid Space  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).