Document 0654
 DOCN  M9490654
 TI    Increased concentrations of soluble tumor necrosis factor receptor 75
       but not of soluble intercellular adhesion molecule-1 are associated with
       the decline of CD4+ lymphocytes in HIV infection.
 DT    9411
 AU    Zangerle R; Fuchs D; Sarcletti M; Gallati H; Reibnegger G; Wachter H;
       Dierich MP; Most J; Department of Dermatology and Venereology,
       University of; Innsbruck, Austria.
 SO    Clin Immunol Immunopathol. 1994 Sep;72(3):328-34. Unique Identifier :
       AIDSLINE MED/94340806
 AB    Immune activation seems to be involved in the pathogenesis of human
       immunodeficiency virus (HIV) infection. The immune activation markers
       neopterin and beta 2-microglobulin can predict the future rate of the
       decrease in CD4+ T cells. In a longitudinal study, we assessed whether
       the decline in the CD4+ T-cell count is associated with increased
       concentrations of soluble intercellular adhesion molecule-1 (sICAM-1)
       and soluble tumor necrosis factor receptor 75 (sTNFR 75), compared to
       increased concentrations of beta 2-microglobulin and urinary neopterin.
       Forty-seven individuals representing all stages of HIV infection were
       followed-up for a mean of 12.7 months (range, 8 to 16 months). The
       percentage of the change of the CD4+ T-cell count from study entry to
       study end ranged from -97 to +98%; the median was -33%. Concentrations
       of urinary neopterin, sTNFR 75, and beta 2-microglobulin correlated with
       the percentage of the change of the CD4+ T-cell count from study entry
       to study end (r = -0.45, confidence interval (CI) -0.65 to -0.19; r =
       -0.42, 95% CI -0.63 to -0.15; and r = -0.416, 95% CI -0.62 to -0.15),
       but those of sICAM-1 did not. This difference was found despite
       significant correlations between sICAM-1 and sTNFR 75 and beta
       2-microglobulin. Levels of sICAM-1 obtained at study entry correlated
       with levels of sICAM-1 obtained at study end (r = 0.46, 95% CI 0.17 to
       0.68). In a multivariate linear regression analysis, urinary neopterin
       and sTNFR 75 were jointly significant for the percentage of the change
       of the CD4+ T-cell count. These results suggest that sTNFR 75 is a
       useful marker to estimate disease progression in HIV infection, whereas
       sICAM-1 does not seem to provide any information related to the decline
       of the CD4+ T-cell count.
 DE    beta 2-Microglobulin/METABOLISM  Adult  Biopterin/ANALOGS &
       DERIVATIVES/URINE  Cell Adhesion Molecules/*BLOOD/CHEMISTRY  Female
       Human  HIV Infections/*IMMUNOLOGY  HIV-1/*IMMUNOLOGY  Leukocyte Count
       Male  Receptors, Tumor Necrosis Factor/CHEMISTRY/*METABOLISM  Solubility
       T4 Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

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