Document 0670
 DOCN  M9490670
 TI    [Childhood visceral leishmaniasis in the Alpes-Maritimes from 1985 to
       1992]
 DT    9411
 AU    Marty P; Leger I; Albertini M; Gari-Toussaint M; Tommasi C; Manassero J;
       Le Fichoux Y; Mariani R; Clinique Medicale Infantile, Hopital de Cimiez,
       Nice.
 SO    Bull Soc Pathol Exot. 1994;87(2):105-9. Unique Identifier : AIDSLINE
       MED/94339723
 AB    Here, we present an analysis of clinical and biological data from 15
       infantile visceral leishmaniasis recorded between 1985 and 1992 in the
       French department of Alpes-Maritimes. The association of fever,
       splenomegalia, tricytopenia remains the most constant and predictive of
       diagnosis (90% of cases). Bone marrow smear affirms diagnosis in 93% of
       cases. Leishmania infantum MON-1 is the causative agent. Except for one
       case of advanced stade with severe hepatic lesions and one case of
       clinical resistance to Glucantime, prognosis is favourable under
       treatment with antimony derivatives. The long term results for children
       considered cured after initial treatment is satisfactory. In the
       department, the number of cases of combined ages has increased regularly
       since 1985. The number of infantile forms has increased but now
       represents nevertheless no more than 28% of total cases. On the other
       hand, cases are increasing in adults and 40% of those adult cases are in
       HIV positive patients.
 DE    Adolescence  Adult  Animal  Antimony/ADMINISTRATION & DOSAGE/THERAPEUTIC
       USE  Antiprotozoal Agents/ADMINISTRATION & DOSAGE/THERAPEUTIC USE  Bone
       Marrow/PARASITOLOGY  Case Report  Child  Child, Preschool  English
       Abstract  Female  France/EPIDEMIOLOGY  Human  Infant  *Leishmania
       infantum/ISOLATION & PURIF  Leishmaniasis, Visceral/DIAGNOSIS/DRUG
       THERAPY/*EPIDEMIOLOGY/  PHYSIOPATHOLOGY  Male  Meglumine/ADMINISTRATION
       & DOSAGE/THERAPEUTIC USE  Organometallic Compounds/ADMINISTRATION &
       DOSAGE/THERAPEUTIC USE  Retrospective Studies  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).