Document 0675
 DOCN  M9490675
 TI    Neuroimaging and neuropathologic findings in AIDS patient with
       cytomegalovirus infection.
 DT    9411
 AU    Nagamitsu S; Okabayashi S; Dai S; Morimitsu Y; Murakami T; Matsuishi T;
       Motizuki M; Kato H; Department of Pediatrics and Child Health, Kurume
       University; School of Medicine.
 SO    Intern Med. 1994 Mar;33(3):158-62. Unique Identifier : AIDSLINE
       MED/94339563
 AB    This 21-year-old male with hemophilia A developed cytomegalovirus (CMV)
       retinitis associated with acquired immunodeficiency syndrome (AIDS). He
       had a history of numerous blood transfusions. Serum antibody titers
       became positive for human immunodeficiency virus (HIV), when the patient
       was 18 years of age. Three years later, he developed CMV retinitis due
       to his immunosuppression. Ganciclovir (DENOSINE, TANABE SEIYAKU CO.,
       LTD., Osaka, Japan) therapy given for 4 weeks produced a marked
       improvement in the ocular fundal findings, but the neurologic signs and
       symptoms, including headache, hypoesthesia, disorientation, and dementia
       became worse. T2-weighted magnetic resonance imaging (MRI) demonstrated
       a diffuse high intensity area in the periventricular white matter and
       small focal or patchy lesions in the hippocampus, basal ganglia,
       midbrain, medulla oblongata and the nucleus dentatus. The patient died
       of HIV encephalopathy and CMV infection. Characteristic CMV intranuclear
       inclusion bodies were observed histologically in most sites of the brain
       including the hippocampus, white matter, basal ganglia, midbrain,
       medulla oblongata, nucleus dentatus and the retina. Infiltration by
       monocyte-macrophage and multinucleated giant cells, which are
       characteristic of HIV encephalopathy, were observed in the
       periventricular white matter and the hippocampus. In this patient, the
       neuroimaging findings were compatible with the neuropathologic
       observations. MR imaging proved useful in detecting the central nervous
       system (CNS) lesions of AIDS and CMV infection.
 DE    Adult  AIDS Dementia Complex/*COMPLICATIONS/*PATHOLOGY/RADIOGRAPHY  Case
       Report  Cytomegalovirus Retinitis/*COMPLICATIONS/*PATHOLOGY
       Hemophilia/COMPLICATIONS  Human  Inappropriate ADH
       Syndrome/COMPLICATIONS  Magnetic Resonance Imaging  Male  Tomography,
       X-Ray Computed  JOURNAL ARTICLE

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