Document 0679
 DOCN  M9490679
 TI    The in vivo effect of ellipticine analogues on the blood concentration
       of Friend virus: a murine model for studying anti-HIV drugs.
 DT    9411
 AU    Mathe G; Chenu E; Bourut C; Orbach-Arbouys S; Institut du cancer et
       d'immunologie, Hopital Suisse de Paris,; Issy-les-Moulineaux, France.
 SO    Biomed Pharmacother. 1993;47(10):457-60. Unique Identifier : AIDSLINE
       MED/94339396
 AB    The viremia of a mouse carrying a murine retrovirus, the Friend virus,
       was taken as a model for screening drugs which could be active on the
       human HIV retrovirus. Ellipticine and two of its analogues injected ip
       at appropriate doses drastically reduced the viremia of the Friend
       virus-injected mice, as measured by transfer of their serum on day 8 of
       the treatment to secondary recipients and numeration, in the spleens of
       the latter, of the foci the remaining virus had induced. Since phase I
       and II trials have already been published (for leukemia treatment), the
       efficacy of those drugs on HIV-1 positive AZT-resistant patients can be
       tested directly.
 DE    Acquired Immunodeficiency Syndrome/*DRUG THERAPY  Animal
       Blood/MICROBIOLOGY  Disease Models, Animal  Ellipticines/*PHARMACOLOGY
       Friend Virus/*DRUG EFFECTS  HIV Infections/DRUG THERAPY  HIV-1/DRUG
       EFFECTS  Male  Mice  Mice, Inbred DBA  Zidovudine/PHARMACOLOGY  JOURNAL
       ARTICLE

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