Document 0697
 DOCN  M9490697
 TI    Cervical intraepithelial neoplasia and human papillomavirus infection
       among Senegalese women seropositive for HIV-1 or HIV-2 or seronegative
       for HIV.
 DT    9411
 AU    Seck AC; Faye MA; Critchlow CW; Mbaye AD; Kuypers J; Woto-Gaye G;
       Langley C; De EB; Holmes KK; Kiviat NB; Department of Infectious
       Diseases, University of Dakar, Senegal.
 SO    Int J STD AIDS. 1994 May-Jun;5(3):189-93. Unique Identifier : AIDSLINE
       MED/94339222
 AB    Studies in various regions of the world have shown that women infected
       with HIV-1 are at increased risk for cervical human papillomavirus (HPV)
       infection as well as for cervical cancer precursor lesions. HIV
       infection and cervical cancer are both widespread in West Africa, but
       little is known about the relationship between HPV and HIV-2, which is
       the predominant type of HIV in the general population of many West
       African countries. To address this issue, we collected cervical samples
       for cytology and HPV analysis from 93 women presenting to the University
       of Dakar Infectious Disease Service (18 women with HIV-1 infection, 17
       with HIV-2 infection, and 58 HIV seronegative controls). Compared to
       those without HIV infection, HIV seropositive women were 13.1 (95% CI =
       2.4, 128) and 11.0 (95% CI = 3.5, 35.8) times more likely to have HPV
       detected using Southern transfer hybridization (STH) and the polymerase
       chain reaction (PCR) respectively. Detection of high and intermediate
       risk HPV types were significantly associated with HIV-1 and HIV-2
       infection. Among HPV positive women, those with, as compared to those
       without HIV infection were more likely to harbour high risk HPV types
       (OR = 9.2, 95% CI = 0.97, 433). HIV-1 and HIV-2 seropositive women were
       23.3 (95% CI = 2.9, 209) and 9.3 (95% CI = 1.1, 79) times more likely to
       have cytological diagnosis of dysplasia, respectively, than were HIV
       seronegative women. Biopsy-proven CIN 3 was found in one woman with
       HIV-1 and invasive cancer was found in one woman with HIV-2.(ABSTRACT
       TRUNCATED AT 250 WORDS)
 DE    Blotting, Southern  Cervical Intraepithelial
       Neoplasia/COMPLICATIONS/*EPIDEMIOLOGY  Cervix
       Dysplasia/COMPLICATIONS/EPIDEMIOLOGY  Cervix
       Neoplasms/COMPLICATIONS/*EPIDEMIOLOGY  Female  Human  *HIV
       Seronegativity  *HIV Seropositivity  HIV-1/*IMMUNOLOGY
       HIV-2/*IMMUNOLOGY  *Papillomavirus, Human  Papovaviridae
       Infections/COMPLICATIONS/*EPIDEMIOLOGY  Polymerase Chain Reaction
       Regression Analysis  Senegal/EPIDEMIOLOGY  Support, U.S. Gov't, P.H.S.
       Tumor Virus Infections/COMPLICATIONS/*EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).