Document 0727
 DOCN  M9490727
 TI    Hypothesis for retroviral causation of rheumatoid arthritis.
 DT    9411
 AU    Wilder RL; Inflammatory Joint Diseases Section, National Institute of;
       Arthritis and Musculoskeletal and Skin Disease, National; Institutes of
       Health, Bethesda, MD 20892.
 SO    Curr Opin Rheumatol. 1994 May;6(3):295-9. Unique Identifier : AIDSLINE
       MED/94338863
 AB    Over the past year, convincing direct evidence that rheumatoid arthritis
       is caused by a retrovirus has not been presented. Strong support for
       this hypothesis, however, comes from an impressive body of recent work
       demonstrating that human T-cell lymphotropic virus type I causes a
       destructive arthropathy that has many of the same features as rheumatoid
       arthritis. Additional strong support for the hypothesis is provided by
       the resemblance of the arthropathies induced by caprine arthritis
       encephalitis and the ovine maedi-visna viruses to rheumatoid arthritis.
       These retroviral infections emphasize the potential complexity of
       detecting retroviral involvement and proving its importance in the
       causation of rheumatoid arthritis. Retroviruses clearly possess diverse
       pathways for involvement in autoimmune diseases.
 DE    Animal  Arthritis-Encephalitis Virus, Caprine/PHYSIOLOGY  Arthritis,
       Rheumatoid/GENETICS/*MICROBIOLOGY  AIDS-Related Opportunistic Infections
       Human  HIV Infections/COMPLICATIONS  HIV-1/PHYSIOLOGY  HIV-2/PHYSIOLOGY
       HTLV-I Infections/COMPLICATIONS  Lentivirus Infections/COMPLICATIONS
       Retroviridae/*PHYSIOLOGY  Retroviridae
       Infections/*COMPLICATIONS/MICROBIOLOGY  RNA, Viral/GENETICS/ISOLATION &
       PURIF  Visna-Maedi Virus/PHYSIOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW,
       TUTORIAL

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