Document 0749
 DOCN  M9490749
 TI    Mortality in HIV-1-seropositive women, their spouses and their newly
       born children during 36 months of follow-up in Kinshasa, Zaire.
 DT    9411
 AU    Ryder RW; Nsuami M; Nsa W; Kamenga M; Badi N; Utshudi M; Heyward WL;
       Project SIDA, Kinshasa, Zaire.
 SO    AIDS. 1994 May;8(5):667-72. Unique Identifier : AIDSLINE MED/94338604
 AB    OBJECTIVE: To calculate 3-year mortality rates in HIV-1-seropositive and
       HIV-1-seronegative mothers, their newborn children and the fathers of
       these children. DESIGN: Longitudinal cohort study of HIV-1-seropositive,
       age and parity-matched HIV-1-seronegative pregnant women, their newborn
       babies and the fathers of these children. SETTING: Obstetric ward and
       follow-up clinic at a large municipal hospital in Kinshasa, Zaire.
       PARTICIPANTS: A total of 335 newborn children and their 327
       HIV-1-seropositive mothers and 341 newborn children and their 337
       HIV-1-seronegative mothers and the fathers of these children. MAIN
       OUTCOME MEASURES: Rates of vertical HIV-1 transmission and maternal,
       paternal and early childhood mortality. RESULTS: The lower and upper
       bounds of vertical transmission were 27 and 50%, respectively. The
       3-year mortality rate was 44% in children with vertically acquired HIV-1
       infection, 25% in children with HIV-1-seropositive mothers and
       indeterminant HIV-1 infection status, and 6% in uninfected children with
       HIV-1-seronegative mothers. HIV-1-seropositive women who transmitted
       HIV-1 infection to their most recently born child had lost a greater
       number of previously born children (mean, 1.5 versus 0.5; P < 0.05),
       were more likely to have had AIDS at delivery (25 versus 12%; P < 0.01)
       and were more likely to die during follow-up (22 versus 9%; P < 0.01)
       than HIV-1-seropositive women who did not transmit HIV-1 infection to
       their newborn child. Twenty-five out of 239 (10.4%) fathers of children
       with HIV-1-seropositive mothers, not lost to follow-up, died compared
       with three out of 310 (1%) fathers of children with HIV-1-seronegative
       mothers (P < 0.01). CONCLUSIONS: Families in Kinshasa, Zaire, in which
       the mother was HIV-1-seropositive experienced a five to 10-fold higher
       maternal, paternal and early childhood mortality rate than families in
       which the mother was HIV-1-seronegative.
 DE    Acquired Immunodeficiency Syndrome/MORTALITY  Adult  Cohort Studies
       Diseases in Twins/EPIDEMIOLOGY  Family Health  Fathers  Female  Human
       HIV Infections/CONGENITAL/EPIDEMIOLOGY/TRANSMISSION  HIV
       Seropositivity/*MORTALITY  *HIV-1  Infant, Newborn  Life Tables  Male
       Parity  Pregnancy  Pregnancy Complications, Infectious/*EPIDEMIOLOGY
       Prospective Studies  Sexual Partners  Survival Analysis
       Zaire/EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).